A New Era in Environmental Chemical
Testing: ToxCast Phase I Chemicals Announced
Washington, D.C. - Aug.
2, 2007) Riding the wave of the future, EPA's ToxCastTM
program looks to revolutionize the agency's chemical toxicity evaluation
Today, EPA's National Center for Computational Toxicology released a list
of 340 chemicals that will be evaluated under Phase I of the ToxCastTM
research program. This three-phased program sets priorities for toxicity
testing of environmental chemicals in order to more efficiently obtain
critical information necessary to protect people and the environment.
"When complete, the ToxCast™ Program will allow EPA to test thousands of
environmental chemicals quickly for harmful effects. EPA will enter a new
era of environmental chemical testing, which will allow the agency to
better protect human health and the environment," said Dr. George Gray,
assistant administrator for the Office of Research and Development.
Under Phase I of ToxCastTM, the chemicals will be
examined in hundreds of different rapid computer tests referred to as high
throughput screening (HTS) bioassays. Phase I will be used to create
chemical signatures of compounds. These chemical signatures will then be
compared to known toxicity data in this proof-of-concept phase. It is
expected that patterns will emerge that are predictive of compounds that
could cause harm to people and the environment. Results of Phase I are
expected in 2008, and will be posted on the ToxCastTM Web site.
Phase II will involve a larger, more diverse set of chemicals to test the
predictability of patterns identified in Phase I. In Phase III, ToxCastTM
will expand the list to thousands of environmental chemicals, delivering
an affordable, science-based system for decision-makers.
In May 2007, the
National Academy of Sciences released a report calling on EPA and other
federal scientific agencies to use advances in computers, genomics and
cellular biology to speed up toxicity testing. The ToxCastTM
Program which began in 2006 implements many of the reports
More information on ToxCast: